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College picks for Week 13: Big Ten, SEC showdowns lead Top 25 schedule

by November 20, 2025
by November 20, 2025

  • Top games include No. 5 Oregon hosting No. 16 Southern California in the Big Ten.
  • In the SEC, No. 8 Oklahoma will face No. 21 Missouri.
  • Other notable contests involve ranked teams like Vanderbilt, BYU, and Georgia Tech.

Week 13 in college football is not entirely a cupcake platter, though admittedly there are a few of those. Fortunately, there are also a number of contests that will challenge our staff panel of pickers.

One of the weekend’s top games is in the western enclave of the Big Ten as No. 5 Oregon hosts No. 16 Southern California. There are actually some meaningful matchups in the SEC as well, most notably No. 8 Oklahoma hosting No. 21 Missouri and No. 13 Vanderbilt taking on a suddenly surging Kentucky squad. The Big 12 headliner features No. 12 Brigham Young heading east to face Cincinnati, and in ACC action No. 16 Georgia Tech entertains Pittsburgh.

Read on to see how our experts think those contests and other games involving the US LBM Coaches Poll Top 25 will go. You can also see how we’ve done thus far throughout the season, though we don’t necessarily recommend that.

This post appeared first on USA TODAY
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