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NFL Week 1 picks: Chiefs or Chargers in Brazil on Friday night?

by September 5, 2025
by September 5, 2025

  • Week 1 will feature four prime-time games between Thursday and Monday.
  • The playoff rematch between Buffalo and Baltimore on Sunday night looms as the game of the weekend.
  • One of our experts picked nearly 73% of the games correctly in 2024.

Since the Philadelphia Eagles won Super Bowl 59 in February, a full 207 days have passed ahead of their 2025 regular-season kickoff opener against the Dallas Cowboys on Thursday night. In between? There was a draft, free agency, Micah Parsons got traded from the Cowboys, Taylor Swift and Travis Kelce got engaged, Nike rolled out some slick new uniforms … but no legit NFL football.

But now our cups runneth over. Following Eagles-Cowboys, the Week 1 smorgasbord rolls onward Friday night, when Kelce’s Kansas City Chiefs face the Los Angeles Chargers in São Paulo, and Swift will reportedly be in attendance at Corinthians Arena.

Sunday’s 13-game stack kicks off with Pittsburgh Steelers QB Aaron Rodgers’ return to ‘JetLife’ Stadium and ends with a playoff rematch between former MVP Lamar Jackson’s Baltimore Ravens and reigning MVP Josh Allen’s Buffalo Bills.

Week 1 ends Monday night in Chicago, where the new-look Bears will host the Minnesota Vikings in QB J.J. McCarthy’s first regular-season start.

Can’t. Wait.

(But to tide you over in the interim, Week 1 picks from USA TODAY Sports’ panel of NFL experts.)

(Odds provided by BetMGM)

  • Dallas Cowboys at Philadelphia Eagles
  • Kansas City Chiefs at Los Angeles Chargers
  • New York Giants at Washington Commanders
  • Tampa Bay Buccaneers at Atlanta Falcons
  • Las Vegas Raiders at New England Patriots
  • Arizona Cardinals at New Orleans Saints
  • Pittsburgh Steelers at New York Jets
  • Miami Dolphins at Indianapolis Colts
  • Cincinnati Bengals at Cleveland Browns
  • Carolina Panthers at Jacksonville Jaguars
  • San Francisco 49ers at Seattle Seahawks
  • Tennessee Titans at Denver Broncos
  • Detroit Lions at Green Bay Packers
  • Houston Texans at Los Angeles Rams
  • Baltimore Ravens at Buffalo Bills
  • Minnesota Vikings at Chicago Bears
This post appeared first on USA TODAY
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