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Who wins in Week 4? Expert picks for college football’s biggest games

by September 18, 2025
by September 18, 2025

  • Several top-ranked college football teams face off in key conference matchups this weekend.
  • No. 12 Oklahoma will begin its SEC schedule against No. 25 Auburn.
  • The Big Ten features a ranked contest between No. 9 Illinois and No. 17 Indiana.

Most of the highest ranked teams in the US LBM Coaches Poll either have this weekend off or will be tuning up against overmatched opponents. But, as college football fans well know, there is no such thing as an uneventful week in this sport. There are plenty of intriguing contests to keep our panel of pickers interested.

As usual, there’s plenty of activity around SEC country as No. 12 Oklahoma kicks off its league slate against No. 25 Auburn and No. 24 South Carolina looks for a bounce-back performance at No. 22 Missouri. There are important contests in the Big Ten as well, with No. 9 Illinois heading to No. 17 Indiana and No. 20 Michigan hitting the road to take on Nebraska. There’s one more ranked pairing, and it’s in the Big 12 where No. 18 Utah hosts No. 16 Texas Tech.

In other games of note, No. 11 Mississippi has a potentially tricky non-conference date with unbeaten Tulane and No. 6 Miami (Fla.) hosts a desperate Florida. Our experts weigh in on where the upsets might happen.

College football picks for Week 4 schedule

This post appeared first on USA TODAY
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