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Miami or Florida State? College football Week 6 picks for Top 25 games

by October 2, 2025
by October 2, 2025

  • Week 6 of the college football season features several key matchups.
  • No. 11 Alabama hosts No. 17 Vanderbilt in a rematch of last season’s upset.
  • No. 3 Miami will travel to face No. 19 Florida State in a Sunshine State showdown.

The Top 25 college football schedule in Week 6 might look fairly tame compared to last weekend’s loaded slate. But that doesn’t mean there won’t be a surprise or two. Our panel of pigskin prognosticators are back to try and figure out where they might happen.

The Saturday headliner features No. 11 Alabama, fresh off its win at Georgia, returning home to take on No. 17 Vanderbilt, as the Commodores look to take down the Crimson Tide for a second consecutive season. The other clash of ranked teams is the Sunshine State showdown as No. 3 Miami heads to Tallahassee to face No. 19 Florida State.

Other games of note include No. 1 Ohio State returning home to meet Minnesota in Big Ten action, a somewhat unexpected battle of unbeatens in the Big 12 with No. 14 Texas Tech visiting Houston, and a couple of playoff teams from a season ago getting together as No. 21 Notre Dame hosts Boise State.

Read on to see what our experts think will happen.

College football Week 6 predictions

This post appeared first on USA TODAY
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